Selected Publications
Here is a highlight of my more recent/ relevant papers and preprints.
In prep:
Belchikov N#, Hu W#, Fan L#, Joglekar A, … Gan L, Tilgner HU. A single-cell long-read isoform resolved case-control study of frontotemporal dementia reveals cell-type specific and broad splicing dysregulation in post-mortem human brain.
Joglekar A#,Foord C#, Jarroux J#, Pollard S, Tilgner HU. Single-cell studies of transcript isoforms.
Preprints:
Joglekar A, Hu W, Zhang B, Narykov O, Diekhans M, …, Ross ME, Tilgner HU. Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development biorxiv
Selected publications:
Stein AN, Joglekar A, Poon CL, Tilgner HU. ScisorWiz: Visualizing Differential Isoform Expression in Single-Cell Long-Read Data. Bioinformatics. 2022 May 23. doi: 10.1093/bioinformatics/btac340. PMID: 35604081.
Hardwick S#, Hu W#, Joglekar A#, Fan L, Collier PG, …, Gan L, Tilgner HU. Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nat Biotechnol. 2022 Mar 7. doi: 10.1038/s41587-022-01231-3. Epub ahead of print. PMID: 35256815
Joglekar A, Prjibelski A, Mahfouz A, Collier P, Lin S, Schlusche AK, Marrocco J, …, Smit AB, Ross ME, Tilgner HU. A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. Nat Commun. 2021 Jan 19;12(1):463. doi: 10.1038/s41467-020-20343-5. PMID: 33469025; PMCID: PMC7815907.
